Certified Ophthalmic Medical Technologist (COMT) 2026 – 400 Free Practice Questions to Pass the Exam

The presence of iris nodules in patients with sarcoid or granular uveitis can represent specific pathological changes that occur in response to inflammation. Koeppe nodules are located at the pupillary margin and are typically associated with anterior uveitis, particularly in cases of infectious or inflammatory etiologies, including sarcoidosis. On the other hand, Busacca nodules are larger, located within the iris stroma, and are more broadly associated with chronic inflammatory conditions, such as granulomatous diseases.

Both types of nodules can arise in sarcoid or granular uveitis, making the recognition of both essential in clinical practice. The presence of either type is indicative of an underlying inflammatory process and can aid in the diagnosis and management of uveitis. Therefore, understanding that both Koeppe and Busacca nodules can appear in such conditions reinforces the need for comprehensive examination and assessment of patients presenting with signs of uveitis.